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Next-gen antivirus technologies
Back in the day, a definition-based antivirus was good enough to catch and get rid of any virus. Basically, the security application was analyzing all the files in the computer, one at a time, determining if their headers contained a specific string of bits or not. To give you an idea, if the header included the (just an example) "434234swwd32@!5$#" string, it meant that the file was infected with the XYZ virus, and the program knew that it had to strip several bits from the file to restore it to its clean state.